The Ampelokipoi district begins from Alexandras Avenue, leading up to the busy crossroads of Kifisias Avenue and Vasilissis Sofias Avenue. Ampelokipoi also borders the eastern suburbs of Gyzi, Psychiko, Galatsi and, Goudi - at the beginning of Mesogeion Avenue. The area was built at a rapid speed, mainly during the 1960s and 1970s.
One of the main arteries in Ampelokipoi is Alexandras Avenue. It begins from Patision Avenue at Pedion tou Areos Park, passing the Radisson Hotel, and ends at the junction of Kifissias and Vasilissis Sofias Avenues.
On its left the area of Gyzi, the Supreme Court of Greece and the Headquarters of the Security Police of Athens. On its right the northern side of Lycabettus Hill and the old Panathinaikos soccer field - Apostolos Nikolaidis - which is slotted to be moved out of the center and turned into a green area within the next few years. Moreover, Ampelokipoi is the seat of the clubs Panathinaikos, one of the most successful Greek sport club, founded in 1908 and Ampelokipoi B.C., a basketball club founded in 1929.
Pedion tou Areos (meaning 'Aresʼ Square'), is the largest green zone in Athens. It is located between Alexandraʼs Avenue and Evelpidon Street. Pedion tou Areos is one of the "lungs" of the city with a major network of sidestreets. The park houses many exhibitions (books, florists, ornaments, etc.) throughout the year. Furthermore, all of the terminals of Attica K.T.E.L. (Intercity Buses) are located on Mavrommateon Street - on its west side.